LINC01614 Promotes Colorectal Cancer Cell Growth and Migration by Regulating miR-217-5p/HMGA1 Axis

Colorectal cancer (CRC) substantially contributes to cancer-related deaths worldwide. Recently, a long non-coding RNA (lncRNA), LINC01614, has emerged as vital gene regulator in progression. Yet, how LINC01614 affects CRC progression remains enigmatic. Here, we defined expression CRC, investigated the performance of cells lacking and elucidated underpinning mechanism. We observed that was upregulated both tissues cell lines. knockdown repressed proliferation metastasis capacity Consistently, an vivo deficiency model exhibited slow tumor growth rate. Moreover, luciferase reporter assay, pull-down, immunoprecipitation confirmed targeted miR-217-5p. reduced HMGA1 N-cadherin, while increasing E-cadherin, resulting decreased viability, proliferation, migration, invasion cells. Our results demonstrate regulates by modulating miR-217-5p/HMGA1 axis, thus holding great potential prognostic biomarker for diagnosis treatment.